
Enhancing brain receptor function with positive allosteric modulation
Aishwarya Segu
A collaborative research by scientists from the National Centre for Biological Sciences (NCBS), Bangalore, and the Institute of Functional Genomics, University of Montpellier, INSERM, CNRS, France, has recently solved the structures of the complex brain receptor—metabotropic glutamate receptor 5 (mGlu5). They describe the binding mode of small molecules known to increase receptor activity, paving the way for new avenues in drug design.