To combat the COVID-19 pandemic and potential future outbreaks, a collaborative study from Shiv Nadar Institute of Eminence (SNIoE), Noida, and other research institutes discovered a chemical compound called STL522228. This promising compound inhibits a crucial protein in the Severe Acute Respiratory Syndrome (SARS) coronavirus, shedding light on the pressing need for effective antiviral treatments.
In a recent collaborative study, researchers from the Institute of Life Sciences, Bhubaneswar, Kalinga Institute of Industrial Technology, Bhubaneswar, International Centre for Genetic Engineering and Biotechnology, New Delhi, and Regional Centre for Biotechnology, Faridabad, uncovered the role of a host protein, nuclear receptor corepressor (NCoR1), in modulating tuberculosis.
Candida infections, caused by pathogenic fungi, pose a significant threat, especially to vulnerable individuals. Researchers from Regional Centre for Biotechnology, Faridabad, Indian Institute of Technology Delhi, Gautam Buddha University, Greater Noida, have developed a gelatin-based platform that closely mimics human skin, aiding in the study of Candida biofilm formation and potentially speeding up drug development to combat these infections.
A research group working on packaging antitumour drugs from Regional Centre for Biotechnology, Faridabad, and Amity University, Haryana, has successfully trained immune cells to attack tumour cells. They have developed a hydrogel-based anticancer drug delivery system that reduces toxicity and targets tumours directly. This innovation shows promise for more effective cancer treatment pending further research and clinical trials.
Researchers from the Indian Institute of Science, Bangalore, have demonstrated Picolinic acid's (PA) potential against pandemic viruses, specifically SARS-CoV-2 and Influenza A, through broad-spectrum antiviral activity and immune response enhancement. The study emphasises PA's promising therapeutic role and its unique mechanism targeting viral entry and immune modulation.
A team of scientists from the National Centre for Biological Sciences (NCBS), Bengaluru, has discovered that mutations not only provide genetic variation but also actively influence evolution, aiding organisms in adapting to new environments. Their study on E. coli revealed that altering mutation biases can lead to a greater number of beneficial mutations, providing new insights into evolution.
A positive highlight of the COVID-19 situation has been the large number of grassroots-level innovations brought forth by Indian start-ups, entrepreneurs, and researchers to counter the pandemic. A thriving culture of innovation and entrepreneurship is necessary to nurture this spirit. In this regard, the fourth edition of the National Bio Entrepreneurship Competition (NBEC) is currently open for applications.