A team of researchers at the SRM Institute of Science and Technology, Chennai, identified a natural compound, cordycepin, to be protective against cadmium-induced toxicity in zebrafish. They found that cordycepin alleviates the gut inflammation, tissue damage, and developmental deficits caused by cadmium exposure in zebrafish. This work holds therapeutic potential for cordycepin in treating cadmium-induced toxicity.
Candida infections, caused by pathogenic fungi, pose a significant threat, especially to vulnerable individuals. Researchers from Regional Centre for Biotechnology, Faridabad, Indian Institute of Technology Delhi, Gautam Buddha University, Greater Noida, have developed a gelatin-based platform that closely mimics human skin, aiding in the study of Candida biofilm formation and potentially speeding up drug development to combat these infections.
A team of researchers at the Regional Centre for Biotechnology (RCB), Faridabad created a mouse model with a deleted MYH3 gene to study congenital musculoskeletal disorders. They found that the loss of this gene led to traits resembling spondylocarpotarsal synostosis syndrome (SCTS) in adult mice, shedding light on MYH3-associated conditions. This work holds promise for understanding rare genetic disorders.
A research group working on packaging antitumour drugs from Regional Centre for Biotechnology, Faridabad, and Amity University, Haryana, has successfully trained immune cells to attack tumour cells. They have developed a hydrogel-based anticancer drug delivery system that reduces toxicity and targets tumours directly. This innovation shows promise for more effective cancer treatment pending further research and clinical trials.
Researchers from the Indian Institute of Science, Bangalore, have demonstrated Picolinic acid's (PA) potential against pandemic viruses, specifically SARS-CoV-2 and Influenza A, through broad-spectrum antiviral activity and immune response enhancement. The study emphasises PA's promising therapeutic role and its unique mechanism targeting viral entry and immune modulation.
In a collaborative study, researchers from the SN Bose National Centre for Basic Sciences, Kolkata, Uluberia College, University of Calcutta, and other institutes made an exciting discovery in treating ulcerative colitis, a prevalent chronic inflammatory bowel disease (IBD). By using chitosan-capped trimanganese tetraoxide nanoparticles, they effectively treated the disease in mice, offering the potential for future therapeutic advancements in this debilitating condition.
A team of researchers at the Indian Institute of Technology (IIT), Kanpur, have identified a key determinant motif in the G protein-coupled receptors (GPCRs) that facilitates its interaction with β-arrestins. The study provides crucial insights into the complex mechanism, opening new avenues for therapeutic interventions and advancing our understanding of GPCR-mediated signalling.