A team of researchers from the Indian Institute of Science, Bengaluru has explored a new approach to treat mycobacterial infections, which are becoming increasingly drug-resistant. They found that a cocktail of mycobacteriophages – viruses that infect mycobacteria but not humans– were effective against slow- and fast-growing mycobacteria, in cultures. This has clinical significance in treating tuberculosis (caused by M.tuberculosis, a slow-growing mycobacterium), which is of concern, especially in developing countries. In this article, Edna George reports on this recent study by Rachit Agarwal’s team.
A team of researchers from the National Institute of Immunology, New Delhi, Indian Institute of Technology Delhi, New Delhi, All India Institute of Medical Sciences, New Delhi, and Agency for Science, Technology and Research (A*STAR), Singapore, has revealed how crosstalk between two molecular pathways in the cells of the gut mediates the aberrant inflammation in Inflammatory Bowel Disease.
Foetal bovine serum is a nutrient-rich additive widely used for in vitro cell culture studies. However, harvesting the serum involves inhuman methods, calling for replacing or reducing its use in experiments. Here is a report on one such ethical step by a team of researchers who found a novel technique to grow skin cells by drastically reducing bovine serum use.
Timely intervention is critical to curbing the spread of vector-borne diseases like malaria. A team of researchers from Mangaluru, Karnataka, has shown that information technology tools such as their Malaria Control System can be powerful allies in anti-malaria programs. Here is a report on how digitisation helped Mangaluru chalk its success story against malaria.
As the world focused on developing coronavirus vaccines, a team of researchers from the National Brain Research Centre (NBRC), Manesar, delved into finding a therapeutic route for COVID-19. They tapped into the rich repository of Ayurvedic herbs and found Mulethi to be a promising candidate. The herb contains an active ingredient that shows potential in alleviating aggressive symptoms of COVID-19. Here is a report on their findings.
The tuberculosis bacteria is notorious for its ability to stay dormant for years within the human body, evading the immune system and always one step away from causing aggressive infection. Now, a study from researchers at Translational Health Science and Technology Institute (THSTI), Faridabad, and Institute of Microbial Technology (IMTech), Chandigarh, has investigated a novel molecular pathway that helps the bacteria avoid the notice of the immune system.
Like a handful of other viruses, the novel coronavirus may also be capable of crossing the placental barrier in pregnant women and infecting the fetus. A recent study from researchers at ICMR-National Institute for Research in Reproductive Health (ICMR-NIRRH) and Indian Institute of Science (IISc), Bengaluru, has examined molecular players in the placenta which may be responsible for allowing the virus to access the developing fetus.