This new study from researchers at IISER Pune delves into the potential biological function of an 'orphan enzyme' using a variety of biochemical, molecular, and structural techniques. Siddhesh Kamat, the Principal Investigator who led this project was recently awarded the EMBO Young Investigators Award as well as the Merck Young Scientist Award.
Researchers at the National Center for Biological Sciences (NCBS), Bengaluru have used a combination of techniques to unravel the mystery of how prions misfold. Prions are proteins that undergo structural changes to form compound assemblies called amyloid fibrils, which can lead to fatal infectious neurodegenerative diseases like the Mad Cow disease and other Transmissible Spongiform Encelopathies in mammals.
Researchers in Hyderabad have successfully expressed and purified a novel antimicrobial protein from the milk of an egg-laying mammal, echidna, using a simple bacterial system. The protein displays antibacterial action against a wide spectrum of bacteria and could be useful in battling drug-resistant pathogens.
Gallbladder cancer has a high rate of incidence in Indian populations and a heavy mortality rate. Now, researchers from ACTREC, Mumbai, have pinpointed a pair of genetic mutations in gallbladder cancer patients, which may serve as potential drug targets for treatment.
Since their initial discovery several decades ago, stem cells have faced intensive study due to their potential medical applications and fascinating biology. A question that has long interested scientists is how do stem cells continue to remain in an undifferentiated or 'uncommitted' state, unlike every other cell type in the body? Now, a new study from researchers at the National Centre for Cell Science (NCCS) sheds light on this unique problem.
The cell is a factory where every component needs to be in its proper place at the proper time for continued function and survival. A new study by researchers at the Indian Institute of Science, Bengaluru, explores how cells manage this remarkable feat of ensuring that the right molecules find their way to the right locations within the cell.
Obesity is an emerging health challenge in India, estimated to affect over 135 million individuals at present. Now, a new study from researchers at the National Institute for Research in Reproductive Health (NIRRH-ICMR) investigates the unexplored link between obesity and male fertility.