Researchers at the Indian Institute of Technology, Jodhpur have identified that the mahogunin ring finger protein–1 (MGRN1) promotes elimination of misfolded proteins; thus alleviating the cytotoxic risk posed by damaged proteins. MGRN1 is involved in the elimination of misfolded proteins via its association with Hsp70 molecular chaperone. Insufficient or retarded abnormal protein elimination in neuronal cells leads to various neurodegenerative diseases such as Alzheimer’s, Huntington, and Parkinson’s, Amyotrophic lateral sclerosis and polyglutamine diseases. A detailed understanding of the molecular mechanism of MGRN1 and efficient upregulation of its quality control function may generate a potential therapeutic opportunity with profound implications for neurodegeneration and aging.