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Research Scientist

 Bengaluru, Karnataka

Profile

Job Description:

  • Biophysical characterization of protein-protein and protein-small molecule interactions by solution NMR spectroscopy
  • Screening of small molecules/Fragments to identify binders that could be further optimized for potency
  • Backbone and side chain assignments using 3D NMR experiments
  • Biophysical characterization of proteins and protein-ligand complexes to facilitate protein science studies (e.g. DLS, ITC, DSC, FP)·
  • Support and enable reproducible large-scale protein purifications in quantity and quality suitable for NMR spectroscopy
  • Regular data analysis, project updates, literature survey and presentations on the target(s)
  • Familiarity with up-to-date laboratory safety protocols and employs them in the course of all work.

Qualification

PhD in Biomolecular NMR with 1-2 years of postdoctoral research experience with peer-reviewed publications in the relevant field

Experience

Expertise in any of the NMR techniques like Water LOGSY, STD, NOESY, HSQC, etc., applied to the study of protein:ligand complexes and fragment-based drug discovery is essentialThe candidate should be able to collect, process data and interpret protein ligand interactions and if needed develop new experiments/pulse programs and analysis scripts.Experience in backbone and sidechain assignments using 3D NMR experiments is essentialHands on experience in recombinant protein expression, purification and N15 labeling is desirableDemonstrated track record in setting up NMR experiments in-house by operating, calibrating 600 and 800 MHz NMR instrumentation is essential

To Apply

Interested candidates may send in the following information by email to jobs-ccbt@instem.res.in

  • Curriculum Vitae (CV)
  • Publication list
  • Contact details of three professional referees
  • Specify "Structural Biology" and your designation in the subject line of your email

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