Project Technical Support-III

 Uttar Pradesh, India


Preclinical Assessment of a Novel Tyrosine Kinase Inhibitor, KKI04 as a Promising Therapeutic Agent for Non-Small Cell Lung Cancer (NSCLC) using Mice xenograft model


Applications are invited for the post of Project Technical Support-III in an ICMR Funded Project (EMDR/SG15/2023 – 1172) up to 24 April 2025. The project will be conducted under the supervision of Professor Deepak Sehgal (Co-Principal Investigator), Department of Life Sciences, School of Natural Sciences, Shiv Nadar Institution of Eminence (Deemed to be University), Delhi NCR.

This proposal aims to study the potent molecule, KKI04’s functional role in vivo for its toxicity, safety, tumor selectivity, and antitumor efficacy in appropriate mice model. The work also aims to develop a few more KKI04 analogs to test their affinity by in vitro studies and their efficacy using mice xenograft models. It will ultimately help to obtain novel inhibitors against T790M/L858R expression and purification of EGFR_TK and EGFR_T790M/L858R proteins using the Baculovirus expression system. To develop inhibition assays of KKI04 and its analog molecules with EGFR_TK and EGFR_T790M/L858R proteins and cell viability.

The selected candidate will be required to make the recombinant baculovirus for expressing the proteins in insect cells. The protein will be purified and characterized using Biochemical and Biophysical parameters. Inhibitors will be identified using in silico and in vitro studies


Up to 24 April 2025 (purely temporary).


Rs. 28,000 + 9 % HRA = Rs. 30520/-PM consolidated


Three years Graduate in Biotechnology / Life Science from a recognized university + three years’ experience or PG in a relevant subject/​field from a recognized university/​Institute


Desirable: Experience on Gene cloning, Protein Expression, and Protein Purification.

To Apply

Eligible and interested candidates should send their application with a complete CV (having personal and academic details including research experiences to Professor Deepak Sehgal (Deepak.​sehgal@​snu.​edu.​in) on or before 23rd May 2024. Only the short-listed candidates will be communicated for an interview around 31st May 2024. NO TA/DA will be given for attending the interview.

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