4th Course on Genome Instability and Human Disease
Genome instability is a hallmark of cancer cells but also a cause of genetic diseases in humans. Our understanding of the causal relationships between genome instability and the development of human diseases rely on our knowledge of the basic mechanisms of DNA and RNA metabolism, from the spatial genome organization to the chromatin landscape up to the regulation of genome expression during development or in response to genotoxic stress. The dysfunctions of these basic mechanisms related to genome metabolism underlie human diseases including cancer, aging, neurological disorders and immune deficiency.
This edition will take place in real-time virtual format (CET, Paris time). Participation is free of charge and participants are selected by the scientific committee (check below the documents needed for application).
Activities (13 PM — 19 PM CET):
Seminars by experts in the field of the mechanisms that maintain genome stability to large scale approaches (molecular signature using NGS and proteomic). Highlight how a research continuum, from basic research to clinical and translational research, provides opportunities to solve human health issues.
Workshops: Carrier development, Scientific communication, Technological workshop, Poster session, “Elevator Pitch”, Students will chair session Poster prize Online Networking events
The main topics are:
Basics mechanisms for maintaining genome stability (repair, replication, DNA damage signaling, spatial genome organization).
Dysfunction of these pathways in human diseases (cancer, aging, immunodeficiency). Molecular signature of Genome Instability.
The DNA Damage Response as anti-cancer therapeutic targets and tools for diagnostic/prognostic.
This international course has two objectives:
Gain knowledge of mechanisms ensuring genome stability, from fundamental molecular pathways (DNA replication, repair, transcription, genome organization) up to large scale approaches (molecular signature using NGS and proteomic).
Highlight how a research continuum, from basic research to clinical and translational research, provides opportunities to solve human health issues.
The educational objectives are :
Encourage the students to speak. Students will ensure the moderator role and introduce speakers + elevator speech
Train students to the evaluation process by awarding themselves the poster prize.