Development of a Drosophila model for environmental enteric dysfunction (EED). Children in low to middle-income countries are continuously exposed to enteric infections, resulting in diarrhoea and malabsorption of nutrients, which ultimately lead to poor growth and stunting. This phenomenon is called EED and we want to develop a fly model to understand what role early life malnutrition plays in this phenomenon. Like the human gut, the fly gut is continuously regenerated. Hence, can early life nutritional insults persist via molecular signatures in adults to influence gut properties such as ability to deal with enteric infections, nutrient absorption and motility?
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