Aggregation of amyloid proteins is believed to play a central role in many neurodegenerative diseases, including Parkinson's disease. Now, a collaborative study by Indian researchers has explored certain key biophysical processes that are involved in the initial steps of this process, providing us with an important clue about the early stages of Parkinson's disease progression.
Our brains are quite proficient at recognizing jumbled words and reading them correctly. Researchers from the Indian Institute of Science, Bengaluru, studied this fascinating phenomenon and came up with a computational model that uses artificial neurons to simulate the way the brain processes jumbled words.
In a recent study, researchers at the National Centre for Cell Science (NCCS), Pune have used Cryo-Electronic microscopy to figure out the structure of an "orphan" receptor expressed in the central nervous system. The study provides important insights into the mechanisms via which this receptor functions, and sets a precedent for using Cryo-EM as a powerful tool for molecular investigation.
Complex neurodegenerative disorders present a challenge to researchers who attempt to study them using model systems in the lab. Precisely measuring the behavioural defects which are hallmarks of such diseases in model organisms like the fruitfly can be difficult. Now, a team of researchers have come up with a new assay which can help assess movement-related impairments in fly models of Parkinson's disease.
A new study by researchers at the Indian Institute of Technology, Kanpur has identified a small molecule drug which shows therapeutic promise against Huntington's disease, a fatal neurodegenerative disorder. The molecule prevents the formation of protein clumps or aggregates which are detrimental for the health of neurons.
A sustained collaborative effort from three very different laboratories, including a father-daughter scientific duo, has resulted in the observation that the neurotransmitter serotonin regulates energy levels in neurons with the help of Sirt1, a protein known for its role in ageing and lifespan regulation.
Depression leaves its mark not only in our ability to experience positive emotions, but also in our capacity to learn and form stable memories. A new study by researchers at the National Center for Biological Sciences (NCBS), Bangalore, sheds light on the differences between how unipolar and bipolar depression can affect a person's capacity to update old memories with new information.