As the problem of antibiotic resistance mounts worldwide, there is a pressing need for identifying and testing novel drug targets. Recently, a team of researchers from the Indian Institute of Science Education and Research (IISER), Pune, and the Central Drug Research Institute (CSIR-CDRI), Lucknow, has identified a protein pathway in an antibiotic-resistant bacterial strain which can be targeted using a small molecule to effectively kill the bacteria.
In a new study, researchers from the University of Delhi have shown how spores of the Anthrax bacteria store information in the form of a “phenotypic memory”. This information ensures that when the conditions are favourable, the spores grow into robust, infectious agents.
Researchers in Hyderabad have successfully expressed and purified a novel antimicrobial protein from the milk of an egg-laying mammal, echidna, using a simple bacterial system. The protein displays antibacterial action against a wide spectrum of bacteria and could be useful in battling drug-resistant pathogens.
Researchers have identified a new genus of bacteria that lives in the guts of the common redworm and is capable of degrading a potent neurotoxin that has been responsible for several food-poisoning outbreaks. The researchers have named the new isolate Pradoshia eiseniae, as a tribute to their mentor, the late Indian microbiologist Pradosh Roy.
Toxoplasma gondii is a parasite well known for its ability to alter its hosts behaviour by targeting neurological pathways.Researchers from the University of Delhi have come up with a novel way to counter infection by this intracellular parasite, using a drug that triggers the infected cell's suicide mechanism, thus killing the parasite residing inside it.
Do the same microbial species reside in the guts of people from different parts of India? Researchers from IISER Bhopal decided to carry out an in-depth study of the diversity of Indian gut flora by comparing and contrasting the microbiome of populations from two parts of the country with very disparate diets.
Salmonella typhimurium is a pathogenic bacterium that causes food-borne infections in humans. Researchers from the Regional Centre for Biotechnology, Faridabad, find that Salmonella globally alters a post-translational protein modification called Sumoylation in infected cells and manipulates the host cell’s intracellular transport machinery.