Complex neurodegenerative disorders present a challenge to researchers who attempt to study them using model systems in the lab. Precisely measuring the behavioural defects which are hallmarks of such diseases in model organisms like the fruitfly can be difficult. Now, a team of researchers have come up with a new assay which can help assess movement-related impairments in fly models of Parkinson's disease.
Tuberculosis is an infectious disease that kills lakhs of Indians every year. Early detection of the disease is key to administering treatment; however, this has been hampered by the fact that current diagnostic techniques are often costly and time-consuming. Now, researchers from the Indian Institute of Science, Bengaluru, have come up with an inexpensive paper-based diagnostic device for tuberculosis detection.
As the problem of antibiotic resistance mounts worldwide, there is a pressing need for identifying and testing novel drug targets. Recently, a team of researchers from the Indian Institute of Science Education and Research (IISER), Pune, and the Central Drug Research Institute (CSIR-CDRI), Lucknow, has identified a protein pathway in an antibiotic-resistant bacterial strain which can be targeted using a small molecule to effectively kill the bacteria.
A new study by researchers at the Indian Institute of Technology, Kanpur has identified a small molecule drug which shows therapeutic promise against Huntington's disease, a fatal neurodegenerative disorder. The molecule prevents the formation of protein clumps or aggregates which are detrimental for the health of neurons.
A recurring challenge for combination cancer therapy has been delivering drugs with widely differing properties to the tumour site. Now, researchers at the Regional Centre for Biotechnology, Faridabad, and Amity University, Haryana, have come up with a novel strategy for combining three different drugs into a single package that can induce tumour shrinkage when injected.
Lead is a heavy metal that was once used extensively in paints, gasoline, batteries, plumbing etc. Now, a new study by Indian researchers shows that in addition to its many known toxic effects, lead may lower immunity as well. Through a series of experiments on fruit flies, the researchers have demonstrated a link between lead exposure and susceptibility towards bacterial infections.
The global wound care market is on the rise with exorbitant costs incurred each year for skin wound care. Nature-derived drugs with wound healing properties that can be manufactured at a lower cost are presently a global requirement. Now, a study by scientists at Tezpur University has identified the country’s first wound-healing peptide from snake venom with anti-bacterial, anti-inflammatory and non-enzymatic properties.