Among the few identified global threats of the twenty-first century, antimicrobial resistance holds the pivotal position. Antimicrobial resistance is an increasingly severe threat to the community, health and the environment surrounding us. Therefore, developing new drug molecules, introducing combination therapy, repurposing of already existing drugs, adding new and useful drug delivery systems are the major priorities of the upcoming decades. Also, it is necessary to educate general people and some of the community healthcare professionals through awareness programs about the pros and cons of the indiscriminate use of antimicrobials to prevent the drug abuse and misuse, which might render an adverse effect on future antimicrobial therapy.